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Proviral Turnover During Untreated HIV Infection Is Dynamic and Variable Between Hosts, Impacting Reservoir Composition on ART
Human immunodeficiency virus (HIV) can persist as an integrated provirus, in a transcriptionally repressed state, within infected cells. This small yet enduring pool of cellular reservoirs that harbor replication-competent HIV is the main barrier to cure. Entry of viral sequences into cellular reser...
Autores principales: | Brooks, Kelsie, Omondi, F. Harrison, Liang, Richard H., Sudderuddin, Hanwei, Jones, Bradley R., Joy, Jeffrey B., Brumme, Chanson J., Hunter, Eric, Brumme, Zabrina L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417368/ https://www.ncbi.nlm.nih.gov/pubmed/34489909 http://dx.doi.org/10.3389/fmicb.2021.719153 |
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