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L-3,4-Dihydroxyphenylalanine Recovers Circadian Rhythm Disturbances in the Rat Models of Parkinson's Disease by Regulating the D1R-ERK1/2-mTOR Pathway

Objective: Patients with Parkinson's disease (PD) frequently experience disruptions in the 24-h daily profile of both behavioral and biological markers. However, whether L-3,4-dihydroxyphenylalanine (L-dopa) influences these markers associated with circadian rhythm or not is still an open quest...

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Detalles Bibliográficos
Autores principales: Yang, Shuyuan, Wan, Ying, Wu, Na, Song, Lu, Liu, Zhihua, Zhao, Jiahao, Liu, Ying, Liu, Zhenguo, Gan, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417416/
https://www.ncbi.nlm.nih.gov/pubmed/34489685
http://dx.doi.org/10.3389/fnagi.2021.719885