Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis

Empagliflozin and metformin are widely used for the treatment of type 2 diabetes. These drugs showed marked anti-inflammatory effects in different animal models via enhancing AMPK activity. Yet, the protective anti-inflammatory effects of their combination against ulcerative colitis have not been pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Youssef, Mahmoud E., Abd El-Fattah, Eslam E., Abdelhamid, Amir M., Eissa, Hanan, El-Ahwany, Eman, Amin, Noha A., Hetta, Helal F., Mahmoud, Mohamed H., Batiha, Gaber El-Saber, Gobba, Naglaa, Ahmed Gaafar, Ahmed Gaafar, Saber, Sameh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417441/
https://www.ncbi.nlm.nih.gov/pubmed/34489707
http://dx.doi.org/10.3389/fphar.2021.719984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417441/
https://www.ncbi.nlm.nih.gov/pubmed/34489707
http://dx.doi.org/10.3389/fphar.2021.719984

Ejemplares similares