Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo

A molecular hallmark in Parkinson’s disease (PD) pathogenesis are α-synuclein aggregates. Cerebral dopamine neurotrophic factor (CDNF) is an atypical growth factor that is mostly resident in the endoplasmic reticulum but exerts its effects both intracellularly and extracellularly. One of the benefic...

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Detalles Bibliográficos
Autores principales: Albert, Katrina, Raymundo, Diana P., Panhelainen, Anne, Eesmaa, Ave, Shvachiy, Liana, Araújo, Gabriela R., Chmielarz, Piotr, Yan, Xu, Singh, Aastha, Cordeiro, Yraima, Palhano, Fernando L., Foguel, Debora, Luk, Kelvin C., Domanskyi, Andrii, Voutilainen, Merja H., Huttunen, Henri J., Outeiro, Tiago F., Saarma, Mart, Almeida, Marcius S., Airavaara, Mikko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417450/
https://www.ncbi.nlm.nih.gov/pubmed/33940158
http://dx.doi.org/10.1016/j.ymthe.2021.04.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417450/
https://www.ncbi.nlm.nih.gov/pubmed/33940158
http://dx.doi.org/10.1016/j.ymthe.2021.04.035

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