Cholesterol Is a Dose-Dependent Positive Allosteric Modulator of CCR3 Ligand Affinity and G Protein Coupling

Cholesterol as an allosteric modulator of G protein-coupled receptor (GPCR) function is well documented. This quintessential mammalian lipid facilitates receptor–ligand interactions and multimerization states. Functionally, this introduces a complicated mechanism for the homeostatic modulation of GP...

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Detalles Bibliográficos
Autores principales: van Aalst, Evan, Wylie, Benjamin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417553/
https://www.ncbi.nlm.nih.gov/pubmed/34490352
http://dx.doi.org/10.3389/fmolb.2021.724603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417553/
https://www.ncbi.nlm.nih.gov/pubmed/34490352
http://dx.doi.org/10.3389/fmolb.2021.724603

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