Sulfarotene, a synthetic retinoid, overcomes stemness and sorafenib resistance of hepatocellular carcinoma via suppressing SOS2-RAS pathway

BACKGROUND: Recurrent hepatocellular carcinoma (HCC) shows strong resistance to sorafenib, and the tumor-repopulating cells (TRCs) with cancer stem cell-like properties are considered a driver for its high recurrent rate and drug resistance. METHODS: Suppression of TRCs may thus be an effective ther...

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Detalles Bibliográficos
Autores principales: Qi, Feng, Qin, Wenxing, Zhang, Yao, Luo, Yongde, Niu, Bing, An, Quanlin, Yang, Biwei, Shi, Keqing, Yu, Zhijie, Chen, Junwei, Cao, Xin, Xia, Jinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418008/
https://www.ncbi.nlm.nih.gov/pubmed/34479623
http://dx.doi.org/10.1186/s13046-021-02085-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418008/
https://www.ncbi.nlm.nih.gov/pubmed/34479623
http://dx.doi.org/10.1186/s13046-021-02085-4

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