Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression

Inflammation is associated with the development of anhedonia in major depression (MD), but the pathway by which inflammatory molecules gain access to the brain and lead to anhedonia is not clear. Molecules of the kynurenine pathway (KP), which is activated by inflammation, readily influx into the br...

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Detalles Bibliográficos
Autores principales: Chen, Xiangchuan, Beltran, Diana J., Tsygankova, Valeriya D., Woolwine, Bobbi J., Patel, Trusharth, Baer, Wendy, Felger, Jennifer C., Miller, Andrew H., Haroon, Ebrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418602/
https://www.ncbi.nlm.nih.gov/pubmed/34482366
http://dx.doi.org/10.1038/s41398-021-01587-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418602/
https://www.ncbi.nlm.nih.gov/pubmed/34482366
http://dx.doi.org/10.1038/s41398-021-01587-1

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