Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition

Multiple Myeloma (MM) is an incurable hematologic malignancy of terminally differentiated plasma cells (PCs), where immune interactions play a key role in the control of cancer cell growth and survival. In particular, MM is characterized by a highly immunosuppressive bone marrow microenvironment whe...

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Detalles Bibliográficos
Autores principales: Petillo, Sara, Capuano, Cristina, Molfetta, Rosa, Fionda, Cinzia, Mekhloufi, Abdelilah, Pighi, Chiara, Antonangeli, Fabrizio, Zingoni, Alessandra, Soriani, Alessandra, Petrucci, Maria Teresa, Galandrini, Ricciarda, Paolini, Rossella, Santoni, Angela, Cippitelli, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418610/
https://www.ncbi.nlm.nih.gov/pubmed/34482362
http://dx.doi.org/10.1038/s41419-021-04104-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418610/
https://www.ncbi.nlm.nih.gov/pubmed/34482362
http://dx.doi.org/10.1038/s41419-021-04104-w

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