Cargando…

Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition

Multiple Myeloma (MM) is an incurable hematologic malignancy of terminally differentiated plasma cells (PCs), where immune interactions play a key role in the control of cancer cell growth and survival. In particular, MM is characterized by a highly immunosuppressive bone marrow microenvironment whe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Petillo, Sara, Capuano, Cristina, Molfetta, Rosa, Fionda, Cinzia, Mekhloufi, Abdelilah, Pighi, Chiara, Antonangeli, Fabrizio, Zingoni, Alessandra, Soriani, Alessandra, Petrucci, Maria Teresa, Galandrini, Ricciarda, Paolini, Rossella, Santoni, Angela, Cippitelli, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418610/ https://www.ncbi.nlm.nih.gov/pubmed/34482362 http://dx.doi.org/10.1038/s41419-021-04104-w

Ejemplares similares

NKG2D and Its Ligands: “One for All, All for One”
por: Zingoni, Alessandra, et al.
Publicado: (2018)

NEDD8-activating enzyme inhibition potentiates the anti-myeloma activity of natural killer cells
por: Petillo, Sara, et al.
Publicado: (2023)

NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma
por: Fionda, Cinzia, et al.
Publicado: (2015)

Bone Marrow Stromal Cell-Derived IL-8 Upregulates PVR Expression on Multiple Myeloma Cells via NF-kB Transcription Factor
por: Mekhloufi, Abdelilah, et al.
Publicado: (2020)

Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation
por: Fionda, Cinzia, et al.
Publicado: (2015)

The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells
por: Cerboni, Cristina, et al.
Publicado: (2014)

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay
por: Abruzzese, Maria Pia, et al.
Publicado: (2016)

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production
por: Capuano, Cristina, et al.
Publicado: (2017)

GAS6/TAM signaling pathway controls MICA expression in multiple myeloma cells
por: Kosta, Andrea, et al.
Publicado: (2022)

Cereblon regulates NK cell cytotoxicity and migration via Rac1 activation
por: Fionda, Cinzia, et al.
Publicado: (2021)

The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors
por: Abruzzese, Maria Pia, et al.
Publicado: (2019)

Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance
por: Zingoni, Alessandra, et al.
Publicado: (2017)

SUMOylation and related post-translational modifications in natural killer cell anti-cancer responses
por: Molfetta, Rosa, et al.
Publicado: (2023)

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma
por: Fionda, Cinzia, et al.
Publicado: (2015)

How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation
por: Antonangeli, Fabrizio, et al.
Publicado: (2017)

Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma
por: Soriani, Alessandra, et al.
Publicado: (2013)

Doxorubicin–Mediated miR–433 Expression on Exosomes Promotes Bystander Senescence in Multiple Myeloma Cells in a DDR–Independent Manner
por: Vulpis, Elisabetta, et al.
Publicado: (2023)

Memory NK Cell Features Exploitable in Anticancer Immunotherapy
por: Capuano, Cristina, et al.
Publicado: (2019)

Impact on NK cell functions of acute versus chronic exposure to extracellular vesicle‐associated MICA: Dual role in cancer immunosurveillance
por: Vulpis, Elisabetta, et al.
Publicado: (2022)

Post-translational Mechanisms Regulating NK Cell Activating Receptors and Their Ligands in Cancer: Potential Targets for Therapeutic Intervention
por: Molfetta, Rosa, et al.
Publicado: (2019)

Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming
por: Capuano, Cristina, et al.
Publicado: (2018)

Activation of Lymphocyte Cytolytic Machinery: Where are We?
por: Galandrini, Ricciarda, et al.
Publicado: (2013)

Key Role of the CD56(low)CD16(low) Natural Killer Cell Subset in the Recognition and Killing of Multiple Myeloma Cells
por: Vulpis, Elisabetta, et al.
Publicado: (2018)

Cross-Dressing of Multiple Myeloma Cells Mediated by Extracellular Vesicles Conveying MIC and ULBP Ligands Promotes NK Cell Killing
por: Vulpis, Elisabetta, et al.
Publicado: (2023)

Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis
por: Molfetta, Rosa, et al.
Publicado: (2017)

Harnessing CD16-Mediated NK Cell Functions to Enhance Therapeutic Efficacy of Tumor-Targeting mAbs
por: Capuano, Cristina, et al.
Publicado: (2021)

CD16 pre-ligation by defucosylated tumor-targeting mAb sensitizes human NK cells to γ(c) cytokine stimulation via PI3K/mTOR axis
por: Capuano, Cristina, et al.
Publicado: (2020)

Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them
por: Cippitelli, Marco, et al.
Publicado: (2021)

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10
por: Zingoni, Alessandra, et al.
Publicado: (2020)

(Auto)Antibody Responses Shape Memory NK Cell Pool Size and Composition
por: Capuano, Cristina, et al.
Publicado: (2022)

Impact of SARS-CoV-2 vaccination on FcγRIIIA/CD16 dynamics in Natural Killer cells: relevance for antibody-dependent functions
por: Capuano, Cristina, et al.
Publicado: (2023)

CD155: A Multi-Functional Molecule in Tumor Progression
por: Molfetta, Rosa, et al.
Publicado: (2020)

Hitting More Birds with a Stone: Impact of TGF-β on ILC Activity in Cancer
por: Fionda, Cinzia, et al.
Publicado: (2020)

NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses
por: Zingoni, Alessandra, et al.
Publicado: (2013)

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases
por: Cuollo, Lorenzo, et al.
Publicado: (2020)

Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells
por: Zitti, Beatrice, et al.
Publicado: (2017)

Cancer Exosomes as Conveyors of Stress-Induced Molecules: New Players in the Modulation of NK Cell Response
por: Vulpis, Elisabetta, et al.
Publicado: (2019)

MICA-129 Dimorphism and Soluble MICA Are Associated With the Progression of Multiple Myeloma
por: Zingoni, Alessandra, et al.
Publicado: (2018)

Role of NF-κB Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal Cells
por: Cippitelli, Marco, et al.
Publicado: (2023)

Integrin-mediated Ras–Extracellular Regulated Kinase (ERK) Signaling Regulates Interferon γ Production in Human Natural Killer Cells
por: Mainiero, Fabrizio, et al.
Publicado: (1998)

Cannot write session to /tmp/vufind_sessions/sess_7kcine8juhos5csbognq540scn