Cargando…

Proteomic signatures of myeloid derived suppressor cells from liver and lung metastases reveal functional divergence and potential therapeutic targets

Myeloid-derived suppressor cells (MDSCs) promote immunosuppressive activities in the tumor microenvironment (TME), resulting in increased tumor burden and diminishing the anti-tumor response of immunotherapies. While primary and metastatic tumors are typically the focal points of therapeutic develop...

Descripción completa

Detalles Bibliográficos
Autores principales:	DaSilva, Nicholas A., Barlock, Benjamin J., Guha, Prajna, Ghosh, Chandra C., Trebino, Catherine E., Camberg, Jodi L., Katz, Steven C., Rowley, David C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418613/ https://www.ncbi.nlm.nih.gov/pubmed/34482371 http://dx.doi.org/10.1038/s41420-021-00621-x

Ejemplares similares

The Stress-Active Cell Division Protein ZapE Alters FtsZ Filament Architecture to Facilitate Division in Escherichia coli
por: DiBiasio, Eric C., et al.
Publicado: (2021)

Nucleotide-dependent activities of FtsA regulate the early establishment of a functional divisome during the Escherichia coli cell cycle
por: Morrison, Josiah J., et al.
Publicado: (2023)

Degradation of MinD oscillator complexes by Escherichia coli ClpXP
por: LaBreck, Christopher J., et al.
Publicado: (2020)

Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity
por: Chai, Louis F., et al.
Publicado: (2021)

Degradation of the E. coli antitoxin MqsA by the proteolytic complex ClpXP is regulated by zinc occupancy and oxidation
por: Vos, Margaret R., et al.
Publicado: (2021)

An essential Staphylococcus aureus cell division protein directly regulates FtsZ dynamics
por: Eswara, Prahathees J, et al.
Publicado: (2018)

Metabolic flux regulates growth transitions and antibiotic tolerance in uropathogenic Escherichia coli
por: Morrison, Josiah J., et al.
Publicado: (2023)

Distinct Cell Adhesion Signature Defines Glioblastoma Myeloid-Derived Suppressor Cell Subsets
por: Bayik, Defne, et al.
Publicado: (2022)

Proteome-wide signatures of function in highly diverged intrinsically disordered regions
por: Zarin, Taraneh, et al.
Publicado: (2019)

Hepatobiliary malignancies have distinct peripheral myeloid-derived suppressor cell signatures and tumor myeloid cell profiles
por: Bayik, Defne, et al.
Publicado: (2020)

Neem leaf glycoprotein prevents post-surgical sarcoma recurrence in Swiss mice by differentially regulating cytotoxic T and myeloid-derived suppressor cells
por: Sarkar, Madhurima, et al.
Publicado: (2017)

Myeloid-derived suppressor cells: Cellular missiles to target tumors
por: Chandra, Dinesh, et al.
Publicado: (2013)

Ubiquitinated Proteins in Exosomes Secreted by Myeloid-Derived Suppressor Cells
por: Burke, Meghan C., et al.
Publicado: (2014)

High-Throughput Screening and Proteomic Characterization of Compounds Targeting Myeloid-Derived Suppressor Cells
por: Krumm, Johannes, et al.
Publicado: (2023)

Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition
por: Ghosh, Chandra C., et al.
Publicado: (2022)

Assembly and architecture of Escherichia coli divisome proteins FtsA and FtsZ
por: Morrison, Josiah J., et al.
Publicado: (2022)

Evolutionary Divergent Suppressor Mutations in Conformational Diseases
por: Mesa-Torres, Noel, et al.
Publicado: (2018)

Editorial: Myeloid Derived Suppressor Cells as Disease Modulators
por: Finn, Olivera J., et al.
Publicado: (2020)

Myeloid Derived Suppressor Cells in Chronic Myeloid Leukemia
por: Giallongo, Cesarina, et al.
Publicado: (2015)

Assessing the Future of Solid Tumor Immunotherapy
por: Guha, Prajna, et al.
Publicado: (2022)

Metabolome-Proteome Differentiation Coupled to Microbial Divergence
por: Wilmes, Paul, et al.
Publicado: (2010)

An expanded myeloid derived suppressor cell population does not play a role in gammaherpesvirus-exacerbated breast cancer metastases
por: Nelson, Daniel A, et al.
Publicado: (2012)

HITM-SURE: Hepatic immunotherapy for metastases phase Ib anti-CEA CAR-T study utilizing pressure enabled drug delivery
por: Katz, Steven C, et al.
Publicado: (2020)

Myeloid-Derived Suppressor Cells in Sepsis
por: Lai, Dengming, et al.
Publicado: (2014)

Myeloid-Derived Suppressor Cells in Sepsis
por: Schrijver, Irene T., et al.
Publicado: (2019)

On the origin of myeloid-derived suppressor cells
por: Millrud, Camilla Rydberg, et al.
Publicado: (2016)

Myeloid-derived suppressor cells in gliomas
por: Gieryng, Anna, et al.
Publicado: (2016)

Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes
por: Jamwal, Rohitash, et al.
Publicado: (2020)

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
por: Veglia, Filippo, et al.
Publicado: (2021)

Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression
por: Sigloch, Florian Christoph, et al.
Publicado: (2017)

Myeloid derived suppressor cells: Targets for therapy
por: Waldron, Todd J., et al.
Publicado: (2013)

Myeloid-derived suppressor cells, age and cancer
por: Bowdish, Dawn ME
Publicado: (2013)

Chemotherapeutic targeting of myeloid-derived suppressor cells
por: Alizadeh, Darya, et al.
Publicado: (2014)

Myeloid Derived Suppressor Cells: Fuel the Fire
por: Achyut, B. R., et al.
Publicado: (2014)

Myeloid-Derived Suppressor Cells in Bacterial Infections
por: Ost, Michael, et al.
Publicado: (2016)

Myeloid-Derived Suppressor Cells and Pulmonary Hypertension
por: Bryant, Andrew J., et al.
Publicado: (2018)

The Yin and Yang of Myeloid Derived Suppressor Cells
por: Budhwar, Snehil, et al.
Publicado: (2018)

In Brief: Myeloid‐derived suppressor cells in cancer
por: Solito, S, et al.
Publicado: (2017)

Myeloid-Derived Suppressor Cells in Lung Transplantation
por: Heigl, Tobias, et al.
Publicado: (2019)

Myeloid-Derived Suppressor Cells in Colorectal Cancer
por: Sieminska, Izabela, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_g353fgb45hgketpb4nltcj40c2