Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer

Although most primary estrogen receptor (ER)–positive breast cancers respond well to endocrine therapies, many relapse later as metastatic disease due to endocrine therapy resistance. Over one third of these are associated with mutations in the ligand-binding domain (LBD) that activate the receptor...

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Detalles Bibliográficos
Autores principales: Mayne, Christopher G., Toy, Weiyi, Carlson, Kathryn E., Bhatt, Trusha, Fanning, Sean W., Greene, Geoffrey L., Katzenellenbogen, Benita S., Chandarlapaty, Sarat, Katzenellenbogen, John A., Tajkhorshid, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Signal Transduction and Functional Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419021/
https://www.ncbi.nlm.nih.gov/pubmed/34021071
http://dx.doi.org/10.1158/1541-7786.MCR-20-1017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419021/
https://www.ncbi.nlm.nih.gov/pubmed/34021071
http://dx.doi.org/10.1158/1541-7786.MCR-20-1017

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