ONC212 is a Novel Mitocan Acting Synergistically with Glycolysis Inhibition in Pancreatic Cancer

ONC212 is a fluorinated imipridone with preclinical efficacy against pancreatic and other malignancies. Although mitochondrial protease ClpP was identified as an ONC212-binding target, the mechanism leading to cancer cell death is incompletely understood. We investigated mitochondrial dysfunction an...

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Detalles Bibliográficos
Autores principales: Ferrarini, Isacco, Louie, Anna, Zhou, Lanlan, El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419089/
https://www.ncbi.nlm.nih.gov/pubmed/34224362
http://dx.doi.org/10.1158/1535-7163.MCT-20-0962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419089/
https://www.ncbi.nlm.nih.gov/pubmed/34224362
http://dx.doi.org/10.1158/1535-7163.MCT-20-0962

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