Characterization of Compound-Specific, Concentration-Independent Biophysical Properties of Sodium Channel Inhibitor Mechanism of Action Using Automated Patch-Clamp Electrophysiology

We have developed an automated patch-clamp protocol that allows high information content screening of sodium channel inhibitor compounds. We have observed that individual compounds had their specific signature patterns of inhibition, which were manifested irrespective of the concentration. Our aim i...

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Detalles Bibliográficos
Autores principales: Pesti, Krisztina, Földi, Mátyás C., Zboray, Katalin, Toth, Adam V., Lukacs, Peter, Mike, Arpad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419314/
https://www.ncbi.nlm.nih.gov/pubmed/34497526
http://dx.doi.org/10.3389/fphar.2021.738460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419314/
https://www.ncbi.nlm.nih.gov/pubmed/34497526
http://dx.doi.org/10.3389/fphar.2021.738460

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