Cargando…

CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65

The E3 ubiquitin ligase complex CDC20‐activated anaphase‐promoting complex/Cyclosome (APC/C(CDC20)) plays a critical role in governing mitotic progression by targeting key cell cycle regulators for degradation. Cell division cycle protein 20 homolog (CDC20), the co‐activator of APC/C, is required fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Yangge, Zhang, Min, Liu, Xuejiao, Li, Zheng, Hu, Menglong, Tian, Yueming, Lv, Longwei, Zhang, Xiao, Liu, Yunsong, Zhang, Ping, Zhou, Yongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419691/ https://www.ncbi.nlm.nih.gov/pubmed/34382737 http://dx.doi.org/10.15252/embr.202152576

Ejemplares similares

DUSP5 promotes osteogenic differentiation through SCP1/2‐dependent phosphorylation of SMAD1
por: Liu, Xuejiao, et al.
Publicado: (2021)

Knockdown of CDC20 promotes adipogenesis of bone marrow-derived stem cells by modulating β-catenin
por: Du, Yangge, et al.
Publicado: (2022)

Regulated degradation of the APC coactivator Cdc20
por: Robbins, Jonathan A, et al.
Publicado: (2010)

Asymmetrical methyltransferase PRMT3 regulates human mesenchymal stem cell osteogenesis via miR-3648
por: Min, Zhang, et al.
Publicado: (2019)

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Osteogenic Differentiation by Modulating AMPK/ULK1‐Dependent Autophagy
por: Li, Zheng, et al.
Publicado: (2019)

Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest
por: May, Karen M., et al.
Publicado: (2017)

Aldo-keto reductase family 1 member C1 regulates the osteogenic differentiation of human ASCs by targeting the progesterone receptor
por: Liu, Xuenan, et al.
Publicado: (2021)

Regulation of APC/C(Cdc20) activity by RASSF1A–APC/C(Cdc20) circuitry
por: Chow, C, et al.
Publicado: (2012)

LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation
por: Wang, Yuejun, et al.
Publicado: (2018)

PP2A‐B56 binds to Apc1 and promotes Cdc20 association with the APC/C ubiquitin ligase in mitosis
por: Fujimitsu, Kazuyuki, et al.
Publicado: (2019)

Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast
por: Tan, Grace S, et al.
Publicado: (2013)

APC/C(CDC20) and APC/C play pivotal roles in the process of embryonic development in Artemia sinica
por: Zhang, Mengchen, et al.
Publicado: (2016)

BHLHE40 Maintains the Stemness of PαS Cells In Vitro by Targeting Zbp1 through the Wnt/β-Catenin Signaling Pathway
por: Hu, Menglong, et al.
Publicado: (2023)

APC15 mediates CDC20 auto-ubiquitylation by APC/C(MCC) and MCC disassembly
por: Uzunova, Kristina, et al.
Publicado: (2012)

APC/C(Cdc20)-mediated degradation of Clb4 prompts astral microtubule stabilization at anaphase onset
por: Zucca, Federico, et al.
Publicado: (2022)

Biochemical, biophysical, and functional characterisation of the E3 ubiquitin ligase APC/C regulator CDC20 from Arabidopsis thaliana
por: Cosma, Maria-Alexa, et al.
Publicado: (2022)

Role of phosphorylation of Cdc20 in the regulation of the action of APC/C in mitosis
por: Shevah-Sitry, Danielle, et al.
Publicado: (2022)

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
por: Nilsson, Jakob, et al.
Publicado: (2008)

Bub3 promotes Cdc20-dependent activation of the APC/C in S. cerevisiae
por: Yang, Yang, et al.
Publicado: (2015)

The spindle checkpoint, APC/C(Cdc20), and APC/C(Cdh1) play distinct roles in connecting mitosis to S phase
por: Clijsters, Linda, et al.
Publicado: (2013)

The APC/C(FZY–1/Cdc20) Complex Coordinates With OMA-1 to Regulate the Oocyte-to-Embryo Transition in Caenorhabditis elegans
por: Hu, Yabing, et al.
Publicado: (2021)

Evidence for how APC-C-Cdc20 changes its substrate specificity in mitosis
por: Izawa, Daisuke, et al.
Publicado: (2011)

Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates
por: Kim, Taekyung, et al.
Publicado: (2017)

The Oncogenic Role of APC/C Activator Protein Cdc20 by an Integrated Pan-Cancer Analysis in Human Tumors
por: Wu, Fei, et al.
Publicado: (2021)

The Mitotic Checkpoint Complex binds a second CDC20 to inhibit active APC/C
por: Izawa, Daisuke, et al.
Publicado: (2014)

Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C(Cdc20)
por: Richeson, Katherine V., et al.
Publicado: (2020)

Oscillation of Cdc20–APC/C–mediated CAMDI stability is critical for cortical neuron migration
por: Okuda, Shohei, et al.
Publicado: (2021)

The Role of the APC/C and Its Coactivators Cdh1 and Cdc20 in Cancer Development and Therapy
por: Greil, Christine, et al.
Publicado: (2022)

RSPO3-LGR4 Regulates Osteogenic Differentiation Of Human Adipose-Derived Stem Cells Via ERK/FGF Signalling
por: Zhang, Min, et al.
Publicado: (2017)

Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1
por: Mann, Guy, et al.
Publicado: (2022)

Defining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 Inhibition
por: D'Arcy, Sheena, et al.
Publicado: (2010)

Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation
por: Izawa, Daisuke, et al.
Publicado: (2012)

The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium
por: Wang, Weiping, et al.
Publicado: (2014)

SIRT6 promotes osteogenic differentiation of mesenchymal stem cells through BMP signaling
por: Zhang, Ping, et al.
Publicado: (2017)

Inhibition of PTGS1 promotes osteogenic differentiation of adipose-derived stem cells by suppressing NF-kB signaling
por: Wang, Yuejun, et al.
Publicado: (2019)

The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis
por: Li, Zheng, et al.
Publicado: (2022)

APC15 drives the turnover of MCC-Cdc20 to make the Spindle Assembly Checkpoint responsive to kinetochore attachment
por: Mansfeld, Jörg, et al.
Publicado: (2011)

ZIM1 Combined with Hydrogel Inhibits Senescence of Primary PαS Cells during In Vitro Expansion
por: Tian, Yueming, et al.
Publicado: (2023)

Physical and Genetic Associations of the Irc20 Ubiquitin Ligase with Cdc48 and SUMO
por: Richardson, Aaron, et al.
Publicado: (2013)

The Trim39 ubiquitin ligase inhibits APC/C(Cdh1)-mediated degradation of the Bax activator MOAP-1
por: Huang, Nai-Jia, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_lijorno162hej9m16vha9efo28