Analytic Pearson residuals for normalization of single-cell RNA-seq UMI data

BACKGROUND: Standard preprocessing of single-cell RNA-seq UMI data includes normalization by sequencing depth to remove this technical variability, and nonlinear transformation to stabilize the variance across genes with different expression levels. Instead, two recent papers propose to use statisti...

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Detalles Bibliográficos
Autores principales: Lause, Jan, Berens, Philipp, Kobak, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419999/
https://www.ncbi.nlm.nih.gov/pubmed/34488842
http://dx.doi.org/10.1186/s13059-021-02451-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419999/
https://www.ncbi.nlm.nih.gov/pubmed/34488842
http://dx.doi.org/10.1186/s13059-021-02451-7

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