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Analytic Pearson residuals for normalization of single-cell RNA-seq UMI data
BACKGROUND: Standard preprocessing of single-cell RNA-seq UMI data includes normalization by sequencing depth to remove this technical variability, and nonlinear transformation to stabilize the variance across genes with different expression levels. Instead, two recent papers propose to use statisti...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419999/ https://www.ncbi.nlm.nih.gov/pubmed/34488842 http://dx.doi.org/10.1186/s13059-021-02451-7 |