Additive effects of variants of unknown significance in replication repair-associated DNA polymerase genes on mutational burden and prognosis across diverse cancers

BACKGROUND: Defects in replication repair-associated DNA polymerases often manifest an ultra-high tumor mutational burden (TMB), which is associated with higher probabilities of response to immunotherapies. The functional and clinical implications of different polymerase variants remain unclear. MET...

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Detalles Bibliográficos
Autores principales: Ying, Jieer, Yang, Lin, Yin, Jiani C, Xia, Guojie, Xing, Minyan, Chen, Xiaoxi, Pang, Jiaohui, Wu, Yong, Bao, Hua, Wu, Xue, Shao, Yang, Zhu, Lingjun, Cheng, Xiangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420654/
https://www.ncbi.nlm.nih.gov/pubmed/34479923
http://dx.doi.org/10.1136/jitc-2021-002336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420654/
https://www.ncbi.nlm.nih.gov/pubmed/34479923
http://dx.doi.org/10.1136/jitc-2021-002336

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