Cargando…

Extracellular HSP90α Interacts With ER Stress to Promote Fibroblasts Activation Through PI3K/AKT Pathway in Pulmonary Fibrosis

Pulmonary fibrosis is characterized by alveolar epithelial cell injury, lung fibroblast proliferation, differentiation, and extracellular matrix (ECM) deposition. Our previous study indicated that extracellular HSP90α (eHSP90α) promotes pulmonary fibrosis by activating the MAPK signaling pathway. Th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jinming, Zhong, Wenshan, Liu, Yuanyuan, Chen, Weimou, Lu, Ye, Zeng, Zhaojin, Qiao, Yujie, Huang, Haohua, Wan, Xuan, Li, Wei, Meng, Xiaojing, Zou, Fei, Cai, Shaoxi, Dong, Hangming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420756/ https://www.ncbi.nlm.nih.gov/pubmed/34497513 http://dx.doi.org/10.3389/fphar.2021.708462

Ejemplares similares

Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis
por: Liu, Yuanyuan, et al.
Publicado: (2021)

Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis
por: Chen, Weimou, et al.
Publicado: (2021)

GW4869 Can Inhibit Epithelial-Mesenchymal Transition and Extracellular HSP90α in Gefitinib-Sensitive NSCLC Cells
por: Wan, Xuan, et al.
Publicado: (2023)

The role of secreted Hsp90α in HDM-induced asthmatic airway epithelial barrier dysfunction
por: Ye, Cuiping, et al.
Publicado: (2019)

TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts
por: Zhou, Zili, et al.
Publicado: (2023)

Extracellular Hsp90α, which participates in vascular inflammation, is a novel serum predictor of atherosclerosis in type 2 diabetes
por: Ding, Xinyi, et al.
Publicado: (2022)

Baicalin Targets HSP70/90 to Regulate PKR/PI3K/AKT/eNOS Signaling Pathways
por: Hou, Yinzhu, et al.
Publicado: (2022)

Extracellular Hsp90α Supports the ePKM2-GRP78-AKT Axis to Promote Tumor Metastasis
por: Zhang, Shaosen, et al.
Publicado: (2022)

HSP70 and HSP90 Differentially Regulate Translocation of Extracellular Antigen to the Cytosol for Cross-Presentation
por: Kato, Yu, et al.
Publicado: (2012)

Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
por: Zhang, Guohua, et al.
Publicado: (2017)

Overexpression of GmHsp90s, a Heat Shock Protein 90 (Hsp90) Gene Family Cloning from Soybean, Decrease Damage of Abiotic Stresses in Arabidopsis thaliana
por: Xu, Jinyan, et al.
Publicado: (2013)

Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma
por: Bekki, Hirofumi, et al.
Publicado: (2015)

Extracellular Heat Shock Protein-90 (eHsp90): Everything You Need to Know
por: Jay, Daniel, et al.
Publicado: (2022)

Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment
por: Dong, Hangming, et al.
Publicado: (2016)

Targeting extracellular Hsp90: A unique frontier against cancer
por: Sager, Rebecca A., et al.
Publicado: (2022)

Hsp90 facilitates accurate loading of precursor piRNAs into PIWI proteins
por: Izumi, Natsuko, et al.
Publicado: (2013)

Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways
por: Zhao, Qian, et al.
Publicado: (2020)

Extracellular HSP90 Machineries Build Tumor Microenvironment and Boost Cancer Progression
por: Poggio, Pietro, et al.
Publicado: (2021)

Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis
por: Sitko, Krzysztof, et al.
Publicado: (2021)

FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP
por: Tufano, Martina, et al.
Publicado: (2023)

Y‐632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo
por: Wang, Wenqian, et al.
Publicado: (2016)

IL-17A promotes tumorigenesis and upregulates PD-L1 expression in non-small cell lung cancer
por: Liao, Hua, et al.
Publicado: (2023)

Hsp-90 and the biology of nematodes
por: Him, Nik AIIN, et al.
Publicado: (2009)

Mechanisms of Hsp90 regulation
por: Prodromou, Chrisostomos
Publicado: (2016)

Regulatory Mechanisms of Hsp90
por: Prodromou, Chrisostomos
Publicado: (2017)

Inhibitors of HSP90 in melanoma
por: Mielczarek-Lewandowska, Aleksandra, et al.
Publicado: (2019)

Role of HSP90 in Cancer
por: Birbo, Bereket, et al.
Publicado: (2021)

Organismal Roles of Hsp90
por: van Oosten-Hawle, Patricija
Publicado: (2023)

Store-Operated Ca(2+) Entry Plays a Role in HMGB1-Induced Vascular Endothelial Cell Hyperpermeability
por: Zou, Mengchen, et al.
Publicado: (2015)

The Distinct Assignments for Hsp90α and Hsp90β: More Than Skin Deep
por: Chang, Cheng, et al.
Publicado: (2023)

Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis
por: Hsu, Han-Shui, et al.
Publicado: (2017)

The Double-Edged Sword: Conserved Functions of Extracellular Hsp90 in Wound Healing and Cancer
por: Hance, Michael W., et al.
Publicado: (2014)

Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signaling
por: Daoud, Abdelkader, et al.
Publicado: (2017)

The HSP90/Akt pathway may mediate artemether‐induced apoptosis of Cal27 cells
por: Wu, Jianhua, et al.
Publicado: (2019)

Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt’s lymphoma cells by inhibiting AKT and ERK
por: Yuan-Ce, Li, et al.
Publicado: (2023)

Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
por: Park, Sangkyu, et al.
Publicado: (2019)

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
por: Kijima, Toshiki, et al.
Publicado: (2018)

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
por: Lackie, Rachel E., et al.
Publicado: (2017)

Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer
por: Ono, Kisho, et al.
Publicado: (2020)

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery
por: Li, Ting, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_n8hq3p9h3j3d80rdnnsk15dn6r