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Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly(ADP-ribose)
Poly(ADP-ribosyl)ation (PARylation) is a multifaceted post-translational modification, carried out by poly(ADP-ribosyl)transferases (poly-ARTs, PARPs), which play essential roles in (patho-) physiology, as well as cancer therapy. Using NAD(+) as a substrate, acceptors, such as proteins and nucleic a...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421145/ https://www.ncbi.nlm.nih.gov/pubmed/34302489 http://dx.doi.org/10.1093/nar/gkab618 |