Cancer cells are highly susceptible to accumulation of templated insertions linked to MMBIR

Microhomology-mediated break-induced replication (MMBIR) is a DNA repair pathway initiated by polymerase template switching at microhomology, which can produce templated insertions that initiate chromosomal rearrangements leading to neurological and metabolic diseases, and promote complex genomic re...

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Detalles Bibliográficos
Autores principales: Osia, Beth, Alsulaiman, Thamer, Jackson, Tyler, Kramara, Juraj, Oliveira, Suely, Malkova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421209/
https://www.ncbi.nlm.nih.gov/pubmed/34379776
http://dx.doi.org/10.1093/nar/gkab685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421209/
https://www.ncbi.nlm.nih.gov/pubmed/34379776
http://dx.doi.org/10.1093/nar/gkab685

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