Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress

The protein kinase ATR plays pivotal roles in DNA repair, cell cycle checkpoint engagement and DNA replication. Consequently, ATR inhibitors (ATRi) are in clinical development for the treatment of cancers, including tumours harbouring mutations in the related kinase ATM. However, it still remains un...

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Detalles Bibliográficos
Autores principales: Lloyd, Rebecca L, Urban, Vaclav, Muñoz-Martínez, Francisco, Ayestaran, Iñigo, Thomas, John C, de Renty, Christelle, O’Connor, Mark J, Forment, Josep V, Galanty, Yaron, Jackson, Stephen P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421211/
https://www.ncbi.nlm.nih.gov/pubmed/34329458
http://dx.doi.org/10.1093/nar/gkab628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421211/
https://www.ncbi.nlm.nih.gov/pubmed/34329458
http://dx.doi.org/10.1093/nar/gkab628

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