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Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element

The most common form of DNA methylation involves the addition of a methyl group to a cytosine base in the context of a cytosine–phosphate–guanine (CpG) dinucleotide. Genomes from more primitive organisms are more abundant in CpG sites that, through the process of methylation, deamination and subsequ...

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Detalles Bibliográficos
Autores principales: Liu, Xu, Weikum, Emily R, Tilo, Desiree, Vinson, Charles, Ortlund, Eric A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421226/
https://www.ncbi.nlm.nih.gov/pubmed/34289059
http://dx.doi.org/10.1093/nar/gkab605