An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase

Viral RNA-dependent RNA polymerases (RdRPs) play central roles in the genome replication and transcription processes of RNA viruses. RdRPs initiate RNA synthesis either in primer-dependent or de novo mechanism, with the latter often assisted by a ‘priming element’ (PE) within the RdRP thumb domain....

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Detalles Bibliográficos
Autores principales: Zhang, Bu-Yu, Liu, Weichi, Jia, Hengxia, Lu, Guoliang, Gong, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421227/
https://www.ncbi.nlm.nih.gov/pubmed/34365500
http://dx.doi.org/10.1093/nar/gkab666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421227/
https://www.ncbi.nlm.nih.gov/pubmed/34365500
http://dx.doi.org/10.1093/nar/gkab666

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