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An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase
Viral RNA-dependent RNA polymerases (RdRPs) play central roles in the genome replication and transcription processes of RNA viruses. RdRPs initiate RNA synthesis either in primer-dependent or de novo mechanism, with the latter often assisted by a ‘priming element’ (PE) within the RdRP thumb domain....
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421227/ https://www.ncbi.nlm.nih.gov/pubmed/34365500 http://dx.doi.org/10.1093/nar/gkab666 |