Local administration of submicron particle paclitaxel to solid carcinomas induces direct cytotoxicity and immune-mediated tumoricidal effects without local or systemic toxicity: preclinical and clinical studies

This report describes local administration of submicron particle paclitaxel (SPP) (NanoPac®: ~ 800-nm-sized particles with high relative surface area with each particle containing ~ 2 billion molecules of paclitaxel) in preclinical models and clinical trials evaluating treatment of carcinomas. Pacli...

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Detalles Bibliográficos
Autores principales: Verco, Shelagh, Maulhardt, Holly, Baltezor, Michael, Williams, Emily, Iacobucci, Marc, Wendt, Alison, Verco, James, Marin, Alyson, Campbell, Sam, Dorman, Paul, diZerega, Gere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421313/
https://www.ncbi.nlm.nih.gov/pubmed/33159289
http://dx.doi.org/10.1007/s13346-020-00868-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421313/
https://www.ncbi.nlm.nih.gov/pubmed/33159289
http://dx.doi.org/10.1007/s13346-020-00868-4

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