Infection-induced type I interferons critically modulate the homeostasis and function of CD8(+) naïve T cells

Naïve T (Tn) cells require two homeostatic signals for long-term survival: tonic T cell receptor:self-peptide–MHC contact and IL-7 stimulation. However, how microbial exposure impacts Tn homeostasis is still unclear. Here we show that infections can lead to the expansion of a subpopulation of long-l...

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Detalles Bibliográficos
Autores principales: Jergović, Mladen, Coplen, Christopher P., Uhrlaub, Jennifer L., Besselsen, David G., Cheng, Shu, Smithey, Megan J., Nikolich-Žugich, Janko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421345/
https://www.ncbi.nlm.nih.gov/pubmed/34489451
http://dx.doi.org/10.1038/s41467-021-25645-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421345/
https://www.ncbi.nlm.nih.gov/pubmed/34489451
http://dx.doi.org/10.1038/s41467-021-25645-w

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