Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease

Mitochondrial dysfunction is a common hallmark of neurological disorders, and reducing mitochondrial damage is considered a promising neuroprotective therapeutic strategy. Here, we used high-throughput small molecule screening to identify CHIR99021 as a potent enhancer of mitochondrial function. CHI...

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Detalles Bibliográficos
Autores principales: Hu, Di, Sun, Xiaoyan, Magpusao, Anniefer, Fedorov, Yuriy, Thompson, Matthew, Wang, Benlian, Lundberg, Kathleen, Adams, Drew J., Qi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421361/
https://www.ncbi.nlm.nih.gov/pubmed/34489447
http://dx.doi.org/10.1038/s41467-021-25651-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421361/
https://www.ncbi.nlm.nih.gov/pubmed/34489447
http://dx.doi.org/10.1038/s41467-021-25651-y

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