Cargando…

Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease

Mitochondrial dysfunction is a common hallmark of neurological disorders, and reducing mitochondrial damage is considered a promising neuroprotective therapeutic strategy. Here, we used high-throughput small molecule screening to identify CHIR99021 as a potent enhancer of mitochondrial function. CHI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Di, Sun, Xiaoyan, Magpusao, Anniefer, Fedorov, Yuriy, Thompson, Matthew, Wang, Benlian, Lundberg, Kathleen, Adams, Drew J., Qi, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421361/ https://www.ncbi.nlm.nih.gov/pubmed/34489447 http://dx.doi.org/10.1038/s41467-021-25651-y

Ejemplares similares

Cardiac Glycoside Activities Link Na(+)/K(+) ATPase Ion-Transport to Breast Cancer Cell Migration via Correlative SAR
por: Magpusao, Anniefer N., et al.
Publicado: (2014)

Comprehensive behavioral phenotyping of calpastatin-knockout mice
por: Nakajima, Ryuichi, et al.
Publicado: (2008)

Phosphorylation of Calpastatin Negatively Regulates the Activity of Calpain
por: Bai, Yuqiang, et al.
Publicado: (2023)

De novo macrolide–glycolipid macrolactone hybrids: Synthesis, structure and antibiotic activity of carbohydrate-fused macrocycles
por: Desmond, Richard T, et al.
Publicado: (2014)

Role of cerebral cortex in the neuropathology of Huntington's disease
por: Estrada-Sánchez, Ana M., et al.
Publicado: (2013)

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer’s disease models
por: Zhao, Yuanyuan, et al.
Publicado: (2022)

Calpastatin phosphorylation regulates radiation-induced calpain activity in glioblastoma
por: Bassett, Emily A., et al.
Publicado: (2018)

Roles of calpain-calpastatin system (CCS) in human T cell activation
por: Mikosik, Anna, et al.
Publicado: (2016)

Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers
por: Flores-Toro, Joseph, et al.
Publicado: (2021)

Role of Melatonin in Reducing Amphetamine-Induced Degeneration in Substantia Nigra of Rats via Calpain and Calpastatin Interaction
por: Chetsawang, Jirapa, et al.
Publicado: (2017)

Expression of calcineurin, calpastatin and heat shock proteins during ischemia and reperfusion
por: Parameswaran, Sreejit, et al.
Publicado: (2015)

Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels
por: Geng, Degui, et al.
Publicado: (2020)

Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice
por: Virlogeux, Amandine, et al.
Publicado: (2021)

Elevated calpain activity in acute myelogenous leukemia correlates with decreased calpastatin expression
por: Niapour, M, et al.
Publicado: (2012)

The Calpain/Calpastatin System Has Opposing Roles in Growth and Metastatic Dissemination of Melanoma
por: Raimbourg, Quentin, et al.
Publicado: (2013)

Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin
por: Nguyen, Hung Huy, et al.
Publicado: (2017)

Calpastatin peptide attenuates early brain injury following experimental subarachnoid hemorrhage
por: Teng, Fei, et al.
Publicado: (2020)

Distinct Changes in Calpain and Calpastatin during PNS Myelination and Demyelination in Rodent Models
por: Miller, John A., et al.
Publicado: (2022)

Overexpression of a Minimal Domain of Calpastatin Suppresses IL-6 Production and Th17 Development via Reduced NF-κB and Increased STAT5 Signals
por: Iguchi-Hashimoto, Mikiko, et al.
Publicado: (2011)

Editorial: New insight into Huntington's disease: From neuropathology to possible therapeutic targets
por: Estrada-Sánchez, Ana María, et al.
Publicado: (2023)

Over-Expression of Calpastatin Inhibits Calpain Activation and Attenuates Post-Infarction Myocardial Remodeling
por: Ye, Tingqiao, et al.
Publicado: (2015)

Association of μ-Calpain and Calpastatin Polymorphisms with Meat Tenderness in a Brahman–Angus Population
por: Leal-Gutiérrez, Joel D., et al.
Publicado: (2018)

Unexpected role of the L-domain of calpastatin during the autoproteolytic activation of human erythrocyte calpain
por: De Tullio, Roberta, et al.
Publicado: (2018)

Effects of calpastatin gene polymorphism on hematology and selected serum biochemical parameters in Awassi lambs
por: Jawasreh, Khaleel Ibrahem, et al.
Publicado: (2019)

Calpastatin-Mediated Inhibition of Calpain Ameliorates Skin Scar Formation after Burn Injury
por: Seo, Cheong Hoon, et al.
Publicado: (2021)

Calpastatin Gene (CAST) Is Not Associated with Late Onset Sporadic Parkinson’s Disease in the Han Chinese Population
por: Zhang, Lan, et al.
Publicado: (2013)

Calpastatin Overexpression Preserves Cognitive Function Following Seizures, While Maintaining Post-Injury Neurogenesis
por: Machado, Vanessa M., et al.
Publicado: (2017)

Polymorphism of prolactin, growth differentiation factor 9, and calpastatin genes and their effects on weight traits in Awassi lambs
por: Ibrahem Jawasreh, Khaleel, et al.
Publicado: (2018)

Relationships between Hha1 Calpastatin Gene Polymorphism, Growth Performance, and Meat Characteristics of Awassi Sheep
por: Jawasreh, Khaleel I., et al.
Publicado: (2019)

Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin
por: Williams, Justin N., et al.
Publicado: (2023)

Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease
por: Zhang, Xinwen, et al.
Publicado: (2020)

Clinical Severity of β-thalassaemia/Hb E Disease Is Associated with Differential Activities of the Calpain-Calpastatin Proteolytic System
por: Sukati, Suriyan, et al.
Publicado: (2012)

Developmental malformations in Huntington disease: neuropathologic evidence of focal neuronal migration defects in a subset of adult brains
por: Hickman, R. A., et al.
Publicado: (2021)

Transplanted Long-Term Cultured Pre-Bi Cells Expressing Calpastatin Are Resistant to B Cell Receptor–Induced Apoptosis
por: Ruiz-Vela, Antonio, et al.
Publicado: (2001)

Ischemia and Reperfusion Induce Differential Expression of Calpastatin and Its Homologue High Molecular Weight Calmodulin-Binding Protein in Murine Cardiomyocytes
por: Parameswaran, Sreejit, et al.
Publicado: (2014)

A novel rhesus macaque model of Huntington’s disease recapitulates key neuropathological changes along with motor and cognitive decline
por: Weiss, Alison R, et al.
Publicado: (2022)

Post‐mortem 7T MR imaging and neuropathology in middle stage juvenile‐onset Huntington disease: A case report
por: Bakels, Hannah S., et al.
Publicado: (2022)

Induced Pluripotent Stem Cell-Derived Neural Stem Cell Transplantations Reduced Behavioral Deficits and Ameliorated Neuropathological Changes in YAC128 Mouse Model of Huntington's Disease
por: Al-Gharaibeh, Abeer, et al.
Publicado: (2017)

Molecule of the month: miRNA and Huntington's disease (HD)
por: Shapshak, Paul
Publicado: (2013)

Expression of calpain-calpastatin system (CCS) member proteins in human lymphocytes of young and elderly individuals; pilot baseline data for the CALPACENT project
por: Mikosik, Anna, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_0slpeo7ubeplbkrks2nkv06a0n