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Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease
Mitochondrial dysfunction is a common hallmark of neurological disorders, and reducing mitochondrial damage is considered a promising neuroprotective therapeutic strategy. Here, we used high-throughput small molecule screening to identify CHIR99021 as a potent enhancer of mitochondrial function. CHI...
Autores principales: | Hu, Di, Sun, Xiaoyan, Magpusao, Anniefer, Fedorov, Yuriy, Thompson, Matthew, Wang, Benlian, Lundberg, Kathleen, Adams, Drew J., Qi, Xin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421361/ https://www.ncbi.nlm.nih.gov/pubmed/34489447 http://dx.doi.org/10.1038/s41467-021-25651-y |
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