Mitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseases

Macroautophagic recycling of dysfunctional mitochondria, known as mitophagy, is essential for mitochondrial homeostasis and cell viability. Accumulation of defective mitochondria and impaired mitophagy have been widely implicated in many neurodegenerative diseases, and loss-of-function mutations of...

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Detalles Bibliográficos
Autores principales: Tjahjono, Elissa, Pei, Jingqi, Revtovich, Alexey V., Liu, Terri-Jeanne E., Swadi, Alisha, Hancu, Maria C., Tolar, Joe G., Kirienko, Natalia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421394/
https://www.ncbi.nlm.nih.gov/pubmed/34489512
http://dx.doi.org/10.1038/s41598-021-97148-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421394/
https://www.ncbi.nlm.nih.gov/pubmed/34489512
http://dx.doi.org/10.1038/s41598-021-97148-z

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