C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers

Nuclear import receptors (NIRs) not only transport RNA-binding proteins (RBPs) but also modify phase transitions of RBPs by recognizing nuclear localization signals (NLSs). Toxic arginine-rich poly-dipeptides from C9orf72 interact with NIRs and cause nucleocytoplasmic transport deficit. However, the...

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Detalles Bibliográficos
Autores principales: Nanaura, Hitoki, Kawamukai, Honoka, Fujiwara, Ayano, Uehara, Takeru, Aiba, Yuichiro, Nakanishi, Mari, Shiota, Tomo, Hibino, Masaki, Wiriyasermkul, Pattama, Kikuchi, Sotaro, Nagata, Riko, Matsubayashi, Masaya, Shinkai, Yoichi, Niwa, Tatsuya, Mannen, Taro, Morikawa, Naritaka, Iguchi, Naohiko, Kiriyama, Takao, Morishima, Ken, Inoue, Rintaro, Sugiyama, Masaaki, Oda, Takashi, Kodera, Noriyuki, Toma-Fukai, Sachiko, Sato, Mamoru, Taguchi, Hideki, Nagamori, Shushi, Shoji, Osami, Ishimori, Koichiro, Matsumura, Hiroyoshi, Sugie, Kazuma, Saio, Tomohide, Yoshizawa, Takuya, Mori, Eiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421406/
https://www.ncbi.nlm.nih.gov/pubmed/34489423
http://dx.doi.org/10.1038/s41467-021-25560-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421406/
https://www.ncbi.nlm.nih.gov/pubmed/34489423
http://dx.doi.org/10.1038/s41467-021-25560-0

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