Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction

A promise of genomics in precision medicine is to provide individualized genetic risk predictions. Polygenic risk scores (PRS), computed by aggregating effects from many genomic variants, have been developed as a useful tool in complex disease research. However, the application of PRS as a tool for...

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Detalles Bibliográficos
Autores principales: Sun, Jiangming, Wang, Yunpeng, Folkersen, Lasse, Borné, Yan, Amlien, Inge, Buil, Alfonso, Orho-Melander, Marju, Børglum, Anders D., Hougaard, David M., Melander, Olle, Engström, Gunnar, Werge, Thomas, Lage, Kasper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421428/
https://www.ncbi.nlm.nih.gov/pubmed/34489429
http://dx.doi.org/10.1038/s41467-021-25014-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421428/
https://www.ncbi.nlm.nih.gov/pubmed/34489429
http://dx.doi.org/10.1038/s41467-021-25014-7

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