Growth-coupled selection of synthetic modules to accelerate cell factory development

Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproductio...

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Autores principales: Orsi, Enrico, Claassens, Nico J., Nikel, Pablo I., Lindner, Steffen N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421431/
https://www.ncbi.nlm.nih.gov/pubmed/34489458
http://dx.doi.org/10.1038/s41467-021-25665-6
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author Orsi, Enrico
Claassens, Nico J.
Nikel, Pablo I.
Lindner, Steffen N.
author_facet Orsi, Enrico
Claassens, Nico J.
Nikel, Pablo I.
Lindner, Steffen N.
author_sort Orsi, Enrico
collection PubMed
description Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.
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spelling pubmed-84214312021-09-22 Growth-coupled selection of synthetic modules to accelerate cell factory development Orsi, Enrico Claassens, Nico J. Nikel, Pablo I. Lindner, Steffen N. Nat Commun Comment Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction. Nature Publishing Group UK 2021-09-06 /pmc/articles/PMC8421431/ /pubmed/34489458 http://dx.doi.org/10.1038/s41467-021-25665-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Orsi, Enrico
Claassens, Nico J.
Nikel, Pablo I.
Lindner, Steffen N.
Growth-coupled selection of synthetic modules to accelerate cell factory development
title Growth-coupled selection of synthetic modules to accelerate cell factory development
title_full Growth-coupled selection of synthetic modules to accelerate cell factory development
title_fullStr Growth-coupled selection of synthetic modules to accelerate cell factory development
title_full_unstemmed Growth-coupled selection of synthetic modules to accelerate cell factory development
title_short Growth-coupled selection of synthetic modules to accelerate cell factory development
title_sort growth-coupled selection of synthetic modules to accelerate cell factory development
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421431/
https://www.ncbi.nlm.nih.gov/pubmed/34489458
http://dx.doi.org/10.1038/s41467-021-25665-6
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AT lindnersteffenn growthcoupledselectionofsyntheticmodulestoacceleratecellfactorydevelopment

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