Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling

Mitochondrial retrograde signaling (mito-RTG) triggered by mitochondrial dysfunction plays a potential role in regulating tumor metabolic reprogramming and cellular sensitivity to radiation. Our previous studies showed phos-pyruvate dehydrogenase (p-PDH) and PDK1, which involved in aerobic glycolysi...

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Detalles Bibliográficos
Autores principales: Shi, Yingying, Wang, You, Jiang, Huangang, Sun, Xuehua, Xu, Hui, Wei, Xue, Wei, Yan, Xiao, Guohui, Song, Zhiyin, Zhou, Fuxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421510/
https://www.ncbi.nlm.nih.gov/pubmed/34489398
http://dx.doi.org/10.1038/s41419-021-03984-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421510/
https://www.ncbi.nlm.nih.gov/pubmed/34489398
http://dx.doi.org/10.1038/s41419-021-03984-2

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