Activation of Cph1 causes ß(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner

Masking the immunogenic cell wall epitope ß(1,3)-glucan under an outer layer of mannosylated glycoproteins is an important virulence factor deployed by Candida albicans during infection. Consequently, increased ß(1,3)-glucan exposure (unmasking) reveals C. albicans to the host’s immune system and at...

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Detalles Bibliográficos
Autores principales: Wagner, Andrew S., Hancock, Trevor J., Lumsdaine, Stephen W., Kauffman, Sarah J., Mangrum, Mikayla M., Phillips, Elise K., Sparer, Timothy E., Reynolds, Todd B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423308/
https://www.ncbi.nlm.nih.gov/pubmed/34432857
http://dx.doi.org/10.1371/journal.ppat.1009839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423308/
https://www.ncbi.nlm.nih.gov/pubmed/34432857
http://dx.doi.org/10.1371/journal.ppat.1009839

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