ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation

Inducible regulatory T (iTreg) cells play a central role in immune suppression. As iTreg cells are differentiated from activated T (Th0) cells, cell metabolism undergoes dramatic changes, including a shift from fatty acid synthesis (FAS) to fatty acid oxidation (FAO). Although the reprogramming in f...

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Detalles Bibliográficos
Autores principales: Tian, Miaomiao, Hao, Fengqi, Jin, Xin, Sun, Xue, Jiang, Ying, Wang, Yang, Li, Dan, Chang, Tianyi, Zou, Yingying, Peng, Pinghui, Xia, Chaoyi, Liu, Jia, Li, Yuanxi, Wang, Ping, Feng, Yunpeng, Wei, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423445/
https://www.ncbi.nlm.nih.gov/pubmed/34491895
http://dx.doi.org/10.7554/eLife.62394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423445/
https://www.ncbi.nlm.nih.gov/pubmed/34491895
http://dx.doi.org/10.7554/eLife.62394

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