Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory

The complement system is implicated in synapse loss in the MS hippocampus, but the functional consequences of synapse loss remain poorly understood. Here, in post-mortem MS hippocampi with demyelination we find that deposits of the complement component C1q are enriched in the CA2 subfield, are linke...

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Detalles Bibliográficos
Autores principales: Ramaglia, Valeria, Dubey, Mohit, Malpede, M. Alfonso, Petersen, Naomi, de Vries, Sharon I., Ahmed, Shanzeh M., Lee, Dennis S. W., Schenk, Geert J., Gold, Stefan M., Huitinga, Inge, Gommerman, Jennifer L., Geurts, Jeroen J. G., Kole, Maarten H. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423657/
https://www.ncbi.nlm.nih.gov/pubmed/34170374
http://dx.doi.org/10.1007/s00401-021-02338-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423657/
https://www.ncbi.nlm.nih.gov/pubmed/34170374
http://dx.doi.org/10.1007/s00401-021-02338-8

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