Neuronal spreading and plaque induction of intracellular Aβ and its disruption of Aβ homeostasis

The amyloid-beta peptide (Aβ) is thought to have prion-like properties promoting its spread throughout the brain in Alzheimer’s disease (AD). However, the cellular mechanism(s) of this spread remains unclear. Here, we show an important role of intracellular Aβ in its prion-like spread. We demonstrat...

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Detalles Bibliográficos
Autores principales: Roos, Tomas T., Garcia, Megg G., Martinsson, Isak, Mabrouk, Rana, Israelsson, Bodil, Deierborg, Tomas, Kobro-Flatmoen, Asgeir, Tanila, Heikki, Gouras, Gunnar K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423700/
https://www.ncbi.nlm.nih.gov/pubmed/34272583
http://dx.doi.org/10.1007/s00401-021-02345-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423700/
https://www.ncbi.nlm.nih.gov/pubmed/34272583
http://dx.doi.org/10.1007/s00401-021-02345-9

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