Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion

Many cadherin family proteins are associated with diseases such as cancer. Since cell adhesion requires homodimerization of cadherin molecules, a small-molecule regulator of dimerization would have therapeutic potential. Herein, we describe identification of a P-cadherin-specific chemical fragment t...

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Detalles Bibliográficos
Autores principales: Senoo, Akinobu, Ito, Sho, Nagatoishi, Satoru, Saito, Yutaro, Ueno, Go, Kuroda, Daisuke, Yoshida, Kouhei, Tashima, Takumi, Kudo, Shota, Sando, Shinsuke, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423723/
https://www.ncbi.nlm.nih.gov/pubmed/34493804
http://dx.doi.org/10.1038/s42003-021-02575-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423723/
https://www.ncbi.nlm.nih.gov/pubmed/34493804
http://dx.doi.org/10.1038/s42003-021-02575-3

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