Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding

The role of intestine clock in energy homeostasis remains elusive. Here we show that mice with Bmal1 specifically deleted in the intestine (Bmal1(iKO) mice) have a normal phenotype on a chow diet. However, on a high-fat diet (HFD), Bmal1(iKO) mice are protected against development of obesity and rel...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Fangjun, Wang, Zhigang, Zhang, Tianpeng, Chen, Xun, Xu, Haiman, Wang, Fei, Guo, Lianxia, Chen, Min, Liu, Kaisheng, Wu, Baojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423749/
https://www.ncbi.nlm.nih.gov/pubmed/34493722
http://dx.doi.org/10.1038/s41467-021-25674-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423749/
https://www.ncbi.nlm.nih.gov/pubmed/34493722
http://dx.doi.org/10.1038/s41467-021-25674-5

Ejemplares similares