Dipeptidyl peptidase-4 (DPP4) inhibitor sitagliptin alleviates liver inflammation of diabetic mice by acting as a ROS scavenger and inhibiting the NFκB pathway

As a common chronic metabolic disease, the development of diabetes mellitus (DM) may also be accompanied by liver damage and inflammatory disorders. Sitagliptin is an inhibitor of dipeptidyl peptidase-4 (DPP4, also known as CD26), which is clinically used for DM treatment. However, the mechanism of...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Ke, Jing, Zhu, Ying-jun, Cao, Bin, Yin, Rui-li, Wang, Yan, Wei, Ling-ling, Zhang, Li-jie, Yang, Long-yan, Zhao, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423797/
https://www.ncbi.nlm.nih.gov/pubmed/34493714
http://dx.doi.org/10.1038/s41420-021-00625-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423797/
https://www.ncbi.nlm.nih.gov/pubmed/34493714
http://dx.doi.org/10.1038/s41420-021-00625-7

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