Cargando…

Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons

Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor-β superfamily. It is widely distributed in the central and peripheral nervous systems. Whether and how GDF-15 modulates nociceptive signaling remains unclear. Behaviorally, we found that peripheral GDF-15 signifi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Wei, Zhang, Wen-Wen, Lyu, Ning, Cao, Hong, Xu, Wen-Dong, Zhang, Yu-Qiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423960/ https://www.ncbi.nlm.nih.gov/pubmed/34076854 http://dx.doi.org/10.1007/s12264-021-00709-5

Ejemplares similares

Nav1.7 and Nav1.8: Diabetes-induced Changes in Primary Sensory Neurons in Rats
por: Lv, Jianlin, et al.
Publicado: (2016)

Increase of Sodium Channels (Nav 1.8 and Nav 1.9) in Rat Dorsal Root Ganglion Neurons Exposed to Autologous Nucleus Pulposus
por: Watanabe, Kazuyuki, et al.
Publicado: (2014)

Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2018)

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons
por: Barbosa, Cindy, et al.
Publicado: (2015)

Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability
por: Pristerà, Alessandro, et al.
Publicado: (2012)

Tetrodotoxin, a Candidate Drug for Nav1.1-Induced Mechanical Pain?
por: Mattei, César
Publicado: (2018)

Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas
por: Bird, Emma V, et al.
Publicado: (2013)

Correction: Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability
por: Pristerà, Alessandro, et al.
Publicado: (2013)

CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain
por: Wu, Xiao-Bo, et al.
Publicado: (2016)

Identification of Navβ1 Residues Involved in the Modulation of the Sodium Channel Nav1.4
por: Islas, Angel A., et al.
Publicado: (2013)

The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer
por: Luo, Qianxuan, et al.
Publicado: (2020)

The Tetrodotoxin Binding Site Is within the Outer Vestibule of the Sodium Channel
por: Fozzard, Harry A., et al.
Publicado: (2010)

Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund’s Adjuvant Models of Pain
por: Matson, David J., et al.
Publicado: (2015)

Putting a Pause on Pain: Chemogenetic Silencing of NaV1.8-Positive Sensory Neurons
por: Nippert, Amy R.
Publicado: (2023)

Kir2.1-Nav1.5 Channel Complexes Are Differently Regulated than Kir2.1 and Nav1.5 Channels Alone
por: Utrilla, Raquel G., et al.
Publicado: (2017)

Dexmedetomidine inhibits Tetrodotoxin-resistant Na(v)1.8 sodium channel activity through G(i/o)-dependent pathway in rat dorsal root ganglion neurons
por: Gu, Xi-Yao, et al.
Publicado: (2015)

Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain
por: Liu, Xiao-Dan, et al.
Publicado: (2014)

Effects of (−)-Gallocatechin-3-Gallate on Tetrodotoxin-Resistant Voltage-Gated Sodium Channels in Rat Dorsal Root Ganglion Neurons
por: Zhang, Yan, et al.
Publicado: (2013)

Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis
por: Schuelert, Niklas, et al.
Publicado: (2012)

Analgesia Effect of Enteric Sustained-Release Tetrodotoxin Pellets in the Rat
por: Hong, Bihong, et al.
Publicado: (2020)

Hypotonicity modulates tetrodotoxin-sensitive sodium current in trigeminal ganglion neurons
por: Li, Lin, et al.
Publicado: (2011)

Tetrodotoxin-Resistant Sodium Channels Contribute to Directional Responses in Starburst Amacrine Cells
por: Oesch, Nicholas W., et al.
Publicado: (2010)

Scorpion toxin BmK I directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats
por: Ye, Pin, et al.
Publicado: (2015)

Inhibition of the Cardiac Na(+) Channel Nav1.5 by Carbon Monoxide
por: Elies, Jacobo, et al.
Publicado: (2014)

Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ(1−42)
por: Wang, Xi, et al.
Publicado: (2016)

Batrachotoxin-modified sodium channels in planar lipid bilayers. Characterization of saxitoxin- and tetrodotoxin-induced channel closures
Publicado: (1987)

Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating
Publicado: (1981)

The Tetrodotoxin Receptor of Voltage-Gated Sodium Channels—Perspectives from Interactions with μ-Conotoxins
por: French, Robert J., et al.
Publicado: (2010)

The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels
por: Geffeney, Shana L., et al.
Publicado: (2006)

Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout Mice
por: Weibel, Raphaël, et al.
Publicado: (2013)

Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison
por: Loussouarn, Gildas, et al.
Publicado: (2016)

Role of the voltage-gated sodium channel Nav1.6 in glioma and candidate drugs screening
por: Ai, Yong, et al.
Publicado: (2023)

General mechanism of spider toxin family I acting on sodium channel Nav1.7
por: Yuan, Fu-Chu, et al.
Publicado: (2022)

Two Novel Peptide Toxins from the Spider Cyriopagopus longipes Inhibit Tetrodotoxin-Sensitive Sodium Channels
por: Zhang, Qingfeng, et al.
Publicado: (2020)

Compound heterozygosity in sodium channel Nav1.7 in a family with hereditary erythermalgia
por: Samuels, Mark E, et al.
Publicado: (2008)

Na(+)/Ca(2+) selectivity in the bacterial voltage-gated sodium channel NavAb
por: Corry, Ben
Publicado: (2013)

Electrophysiological characterization of schizophrenia-associated variants in NaV1.2 sodium channel
por: Suslova, M., et al.
Publicado: (2022)

Antinociceptive Effects of AGAP, a Recombinant Neurotoxic Polypeptide: Possible Involvement of the Tetrodotoxin-Resistant Sodium Channels in Small Dorsal Root Ganglia Neurons
por: Li, Chun-Li, et al.
Publicado: (2016)

Supramolecular clustering of the cardiac sodium channel Nav1.5 in HEK293F cells, with and without the auxiliary β3‐subunit
por: Salvage, Samantha C., et al.
Publicado: (2020)

Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of rattlesnake corpus cavernosum
por: De Nucci, Gilberto
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_matn9a77qaq8s9q3rc4m1q3guk