A Low-Prevalence Single-Nucleotide Polymorphism in the Sensor Kinase PhoR in Mycobacterium tuberculosis Suppresses Its Autophosphatase Activity and Reduces Pathogenic Fitness: Implications in Evolutionary Selection

The genome sequencing of Mycobacterium tuberculosis, the causative organism of tuberculosis, has significantly improved our understanding of the mechanisms that drive the establishment of infection and disease progression. Several clinical strains of M. tuberculosis exhibit single-nucleotide polymor...

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Detalles Bibliográficos
Autores principales: Waturuocha, Uchenna Watson, Krishna, M. S., Malhotra, Vandana, Dixit, Narendra M., Saini, Deepak Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424205/
https://www.ncbi.nlm.nih.gov/pubmed/34512602
http://dx.doi.org/10.3389/fmicb.2021.724482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424205/
https://www.ncbi.nlm.nih.gov/pubmed/34512602
http://dx.doi.org/10.3389/fmicb.2021.724482

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