A SHHecret target of relapsed medulloblastoma: Astrocytes

In this issue of JEM, Guo et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202350) examine the importance of tumor-derived astrocytes in SHH-medulloblastoma recurrence. They show that tumor cells transdifferentiate to tumor-derived astrocytes via bone morphogenetic proteins and Sox9, which e...

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Detalles Bibliográficos
Autores principales: Qadeer, Zulekha A., Weiss, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424466/
https://www.ncbi.nlm.nih.gov/pubmed/34398189
http://dx.doi.org/10.1084/jem.20211141
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author Qadeer, Zulekha A.
Weiss, William A.
author_facet Qadeer, Zulekha A.
Weiss, William A.
author_sort Qadeer, Zulekha A.
collection PubMed
description In this issue of JEM, Guo et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202350) examine the importance of tumor-derived astrocytes in SHH-medulloblastoma recurrence. They show that tumor cells transdifferentiate to tumor-derived astrocytes via bone morphogenetic proteins and Sox9, which excitingly can be targeted by BMP inhibitors.
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spelling pubmed-84244662022-03-06 A SHHecret target of relapsed medulloblastoma: Astrocytes Qadeer, Zulekha A. Weiss, William A. J Exp Med Insights In this issue of JEM, Guo et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202350) examine the importance of tumor-derived astrocytes in SHH-medulloblastoma recurrence. They show that tumor cells transdifferentiate to tumor-derived astrocytes via bone morphogenetic proteins and Sox9, which excitingly can be targeted by BMP inhibitors. Rockefeller University Press 2021-08-16 /pmc/articles/PMC8424466/ /pubmed/34398189 http://dx.doi.org/10.1084/jem.20211141 Text en © 2021 Qadeer and Weiss http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Qadeer, Zulekha A.
Weiss, William A.
A SHHecret target of relapsed medulloblastoma: Astrocytes
title A SHHecret target of relapsed medulloblastoma: Astrocytes
title_full A SHHecret target of relapsed medulloblastoma: Astrocytes
title_fullStr A SHHecret target of relapsed medulloblastoma: Astrocytes
title_full_unstemmed A SHHecret target of relapsed medulloblastoma: Astrocytes
title_short A SHHecret target of relapsed medulloblastoma: Astrocytes
title_sort shhecret target of relapsed medulloblastoma: astrocytes
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424466/
https://www.ncbi.nlm.nih.gov/pubmed/34398189
http://dx.doi.org/10.1084/jem.20211141
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