Cargando…
Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau
In Alzheimer’s disease, soluble oligomers of the amyloid-β peptide (Aβ(o)) trigger a cascade of events that includes abnormal hyperphosphorylation of the protein tau, which is essential for pathogenesis. However, the mechanistic link between these two key pathological proteins remains unclear. Using...
Autores principales: | Taylor, Henry B.C., Emptage, Nigel J., Jeans, Alexander F. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424646/ https://www.ncbi.nlm.nih.gov/pubmed/34469725 http://dx.doi.org/10.1016/j.celrep.2021.109638 |
Ejemplares similares
-
A Novel Optical Quantal Analysis of Miniature Events Reveals Enhanced Frequency Following Amyloid β Exposure
por: Taylor, Henry B. C., et al.
Publicado: (2020) -
Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease
por: Pascoal, T A, et al.
Publicado: (2017) -
Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
por: Liu, Jin, et al.
Publicado: (2016) -
Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss
por: Tiwari, Sachin Suresh, et al.
Publicado: (2016) -
Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline
por: Hines, Amelia D., et al.
Publicado: (2023)