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Modulating tumor infiltrating myeloid cells to enhance bispecific antibody-driven T cell infiltration and anti-tumor response

BACKGROUND: Tumor microenvironment (TME) is a dynamic cellular milieu to promote tumor angiogenesis, growth, proliferation, and metastasis, while derailing the host anti-tumor response. TME impedes bispecific antibody (BsAb) or chimeric antigen receptor (CAR)-driven T cells infiltration, survival, a...

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Detalles Bibliográficos
Autores principales: Park, Jeong A., Wang, Linlin, Cheung, Nai-Kong V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424962/
https://www.ncbi.nlm.nih.gov/pubmed/34496935
http://dx.doi.org/10.1186/s13045-021-01156-5