The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis

Background and Aims: Activation of the inflammasome NLRP3 (NOD-, LRR- and pyrin domain containing 3) contributes to the development of non-alcoholic fatty liver disease (NAFLD) and progression to non-alcoholic steatohepatitis (NASH). Therefore, this study explored the therapeutic effects of a novel...

Descripción completa

Detalles Bibliográficos
Autores principales: Torres, Sandra, Brol, Maximilian J, Magdaleno, Fernando, Schierwagen, Robert, Uschner, Frank E., Klein, Sabine, Ortiz, Cristina, Tyc, Olaf, Bachtler, Nadine, Stunden, James, Bertheloot, Damien, Kitanovic, Ana, Sanchez, Brian, Schrum, Jacob, Roush, William R., Franchi, Luigi, Byth, Kate, Latz, Eicke, Trebicka, Jonel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425476/
https://www.ncbi.nlm.nih.gov/pubmed/34513923
http://dx.doi.org/10.3389/fmolb.2021.715765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425476/
https://www.ncbi.nlm.nih.gov/pubmed/34513923
http://dx.doi.org/10.3389/fmolb.2021.715765

Ejemplares similares