Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity

Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting a...

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Detalles Bibliográficos
Autores principales: Sauter, Daniel, Kirchhoff, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425523/
https://www.ncbi.nlm.nih.gov/pubmed/34495970
http://dx.doi.org/10.1371/journal.pbio.3001353
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author Sauter, Daniel
Kirchhoff, Frank
author_facet Sauter, Daniel
Kirchhoff, Frank
author_sort Sauter, Daniel
collection PubMed
description Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response.
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spelling pubmed-84255232021-09-09 Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity Sauter, Daniel Kirchhoff, Frank PLoS Biol Primer Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response. Public Library of Science 2021-09-08 /pmc/articles/PMC8425523/ /pubmed/34495970 http://dx.doi.org/10.1371/journal.pbio.3001353 Text en © 2021 Sauter, Kirchhoff https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Sauter, Daniel
Kirchhoff, Frank
Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity
title Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity
title_full Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity
title_fullStr Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity
title_full_unstemmed Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity
title_short Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity
title_sort less is more: biased loss of cpg dinucleotides strengthens antiviral immunity
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425523/
https://www.ncbi.nlm.nih.gov/pubmed/34495970
http://dx.doi.org/10.1371/journal.pbio.3001353
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