1-Oxo-3,4-dihydroisoquinoline-4-carboxamides as novel druglike inhibitors of poly(ADP-ribose) polymerase (PARP) with favourable ADME characteristics

A novel 3,4-dihydroisoquinol-1-one-4-carboxamide scaffold was designed as the basis for the development of novel inhibitors of poly(ADP-ribose) polymerase (PARP). Synthesis of 3,4-dihydroisoquinol-1-one-4-carboxylic acids was achieved using the previously developed protocol based on the modified Cas...

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Detalles Bibliográficos
Autores principales: Safrygin, Alexander, Zhmurov, Petr, Dar’in, Dmitry, Silonov, Sergey, Kasatkina, Mariia, Zonis, Yulia, Gureev, Maxim, Krasavin, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425678/
https://www.ncbi.nlm.nih.gov/pubmed/34482781
http://dx.doi.org/10.1080/14756366.2021.1972993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425678/
https://www.ncbi.nlm.nih.gov/pubmed/34482781
http://dx.doi.org/10.1080/14756366.2021.1972993

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