De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects

Transient receptor potential vanilloid 1 (TRPV1) ion channel is a nociceptor critically involved in pain sensation. Direct blockade of TRPV1 exhibits significant analgesic effects but also incurs severe side effects such as hyperthermia, causing failures of TRPV1 inhibitors in clinical trials. In or...

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Detalles Bibliográficos
Autores principales: Xu, Lizhen, Zhang, Heng, Wang, Yunfei, Lu, Xiancui, Zhao, Zhenye, Ma, Cheng, Yang, Shilong, Yarov‐Yarovoy, Vladimir, Tian, Yuhua, Zheng, Jie, Yang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425881/
https://www.ncbi.nlm.nih.gov/pubmed/34247451
http://dx.doi.org/10.1002/advs.202101716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425881/
https://www.ncbi.nlm.nih.gov/pubmed/34247451
http://dx.doi.org/10.1002/advs.202101716

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