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De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects
Transient receptor potential vanilloid 1 (TRPV1) ion channel is a nociceptor critically involved in pain sensation. Direct blockade of TRPV1 exhibits significant analgesic effects but also incurs severe side effects such as hyperthermia, causing failures of TRPV1 inhibitors in clinical trials. In or...
Autores principales: | Xu, Lizhen, Zhang, Heng, Wang, Yunfei, Lu, Xiancui, Zhao, Zhenye, Ma, Cheng, Yang, Shilong, Yarov‐Yarovoy, Vladimir, Tian, Yuhua, Zheng, Jie, Yang, Fan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425881/ https://www.ncbi.nlm.nih.gov/pubmed/34247451 http://dx.doi.org/10.1002/advs.202101716 |
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